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Movement Disorder
APOSAN® Pen
For information purposes only
The APOSAN Pen is an advanced, ready-to-use solution for managing motor fluctuations in Parkinson’s disease. Developed by Rusan Pharma, it delivers Apomorphine Hydrochloride with precision and convenience via an easy-to-use injection pen. Designed for rapid relief from "OFF" episodes in patients with advanced Parkinson’s disease, the APOSAN Pen is India’s first indigenously manufactured apomorphine pen, offering both affordability and reliability in PD care. Key Features Generic Name: Apomorphine Hydrochloride Strength: 10 mg/ml Form: Pre-filled, ready-to-inject pen Indication: Management of "OFF" episodes in advanced Parkinson’s disease Administration Route: Subcutaneous injection Onset of Action: Within 4–10 minutes Duration of Effect: Lasts 60–90 minutes
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APOSAN® Pen by Rusan Pharma
How It Works
Apomorphine is a non-ergoline dopamine agonist that mimics the action of dopamine in the brain. When dopamine levels fall and PD symptoms intensify, the APOSAN Pen provides fast-acting symptom relief by stimulating dopamine receptors, helping restore motor function during "OFF" periods.
Usage Instructions
Use as directed by a neurologist or trained healthcare professional.
The pen is designed for subcutaneous injection, typically in the abdomen or thigh.
Follow priming and dosing instructions provided with the device.
Monitor for response and adjust dosing only under medical supervision.
Who Can Use It
Patients diagnosed with advanced Parkinson’s disease experiencing frequent "OFF" episodes that are not controlled by oral medications.
Individuals who are candidates for rescue therapy to regain mobility during sudden symptom flare-ups.
Safety Information & Precautions
Medical Supervision Required: Always use under the guidance of a neurologist.
Nausea Prevention: May be initiated alongside an antiemetic (e.g., domperidone) to reduce nausea.
Contraindications: Not recommended for patients with severe hypotension, liver disease, or allergy to apomorphine.
Potential Drug Interactions: Avoid using with certain drugs that prolong QT interval (e.g., sotalol, moxifloxacin).
Pregnancy/Breastfeeding: Use only if prescribed; consult a healthcare provider.
Common Side Effects
Nausea and vomiting
Injection site irritation
Drowsiness or dizziness
Orthostatic hypotension (drop in blood pressure when standing)
Storage Instructions
Store below 25°C and protect from direct sunlight.
Do not freeze.
Once opened, follow usage duration guidelines as per manufacturer instructions.
Keep out of reach of children.
Benefits
Fast Relief of “OFF” Episodes: Rapid onset improves mobility and daily function.
Discreet & Portable: Easy to carry and use at home or in public settings.
User-Friendly Design: Simplifies self-administration with minimal training.
Cost-Effective: Available at a fraction of the price of international alternatives.
Rapid Action: Starts working within 4 to 10 minutes.
Duration of Action: Effects last for 60 to 90 minutes.
Non-Addictive: Does not contain morphine and is not a controlled substance.
Improves Quality of Life: Reduces "OFF" time and improves sleep, reducing hallucinations and dyskinesia.
FAQs
1. What is the APOSAN Pen used for?
It is used to treat sudden "OFF" episodes in patients with advanced Parkinson’s disease.
2. How quickly does the APOSAN Pen work?
It begins working within 4–10 minutes after injection.
3. Is the APOSAN Pen difficult to use?
No, it is designed for easy self-injection with simple steps. Your healthcare provider will train you on its use.
4. Can the APOSAN Pen be reused?
The pen contains multiple doses but should be used as per your doctor’s instructions. Do not reuse needles.
5. Is this a morphine-based product?
No. Although it shares a similar name, Apomorphine does not contain morphine and is not addictive.
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