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Movement Disorder
APOSAN® Pump
For information purposes only
The APOSAN® Pump is an advanced drug delivery system developed by Rusan Pharma for the continuous subcutaneous infusion of Apomorphine Hydrochloride. It is designed to manage severe and unpredictable "OFF" episodes in patients with advanced Parkinson’s disease who no longer respond adequately to oral therapy. The APOSAN® Pump offers India’s first indigenously produced apomorphine pump therapy at an affordable cost, providing consistent, all-day symptom control. Key Features Generic Name: Apomorphine Hydrochloride Strength: 10 mg/ml Form: Pre-filled ampoules (2 ml and 5 ml) for use in infusion pumps Indication: Management of motor fluctuations ("ON–OFF" episodes) in chronic Parkinson’s disease Delivery Method: Continuous subcutaneous infusion via wearable pump Onset of Action: Begins working within minutes Customizable Dosing: Infusion rates tailored to patient needs
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APOSAN Pump by Rusan Pharma – Continuous Relief for Parkinson’s Disease
Administration and Usage
Initiation: Treatment begins under medical supervision with dose titration and patient or caregiver training
Infusion Duration: Typically 12 to 16 hours per day, depending on individual response
Injection Sites: Usually the abdomen or thigh, with regular rotation to avoid skin irritation
Needle/Cannula: Can be used with soft cannulas or steel needles based on patient comfort
Ampoule Replacement: Ampoules are replaced daily or as per the doctor's prescription
Safety Information
Prescription Requirement: APOSAN® Pump therapy must be initiated and monitored by a healthcare professional
Contraindications: Not recommended for individuals with known hypersensitivity to apomorphine, severe hypotension, or significant liver impairment
Pre-treatment: An antiemetic (such as domperidone) may be prescribed to prevent nausea
Device Handling: Proper training is required for safe use at home
Storage: Store ampoules at a temperature below 25°C. Protect from light. Do not freeze
Compatibility: Use only with compatible infusion pumps as recommended by your doctor
Possible Side Effects
Nausea and vomiting
Injection site reactions such as redness or lumps
Drowsiness or dizziness
Drop in blood pressure when standing
Rarely, hallucinations in elderly patients
Report any serious or unexpected side effects to your healthcare provider immediately.
Benefits
Provides consistent symptom control throughout the day
Reduces "OFF" time and increases "ON" periods without excessive involuntary movements
Improves daily function and mobility
Customizable dosing to suit individual patient needs
Improves quality of life by reducing anxiety and unpredictability in symptoms
Ideal for patients who cannot tolerate or do not respond well to oral medication
More affordable compared to imported infusion therapies
Frequently Asked Questions
What is the APOSAN® Pump used for?
It is used for continuous relief from motor symptoms in patients with advanced Parkinson’s disease.
How is the APOSAN® Pump different from the APOSAN® Pen?
The APOSAN® Pen provides quick rescue doses during "OFF" episodes, while the APOSAN® Pump delivers a steady, continuous dose throughout the day for more consistent control.
Can I use the APOSAN® Pump at home?
Yes. Once your healthcare provider has trained you or your caregiver and adjusted your dosage, you can use the pump at home.
Is using the pump painful?
Most patients adapt well. Mild discomfort may occur initially at the infusion site, but this usually improves with time and proper site rotation.
Is the APOSAN® Pump suitable for long-term treatment?
Yes. With regular medical supervision, the APOSAN® Pump can be safely used for long-term symptom management.
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